Fresno State was trailing by five at the midway mark in the first half, but stormed ahead with a 17-3 run sparked by a 3-pointer and two jumpers from Watson. Edo made a layup and then dunked to give the Bulldogs a 36-27 halftime lead.
UC Irvine (3-3) pulled within seven after Aaron Wright's three-point play with 8:20 remaining, but Watson answered right back with a 3. The Anteaters couldn't trim the deficit any further until putting together a late run with the game well in hand.
Will Davis II paced UC Irvine with 12 points and 10 rebounds.