The team hit just 37.7 percent from the field and 61.8 percent from the line.
With the Panthers leading 59-57 in the final seconds of regulation, George Mason's Marquise Moore drew a foul and then hit both free throws, sending the game into overtime.
In the extra period, Tuttle hit a layup with less than a minute to play and Jesperson sank two from the line to help the Panthers to the win.
Moore led the Patriots (2-6) with 20 points. Shevon Thompson had nine points and a team-high 11 boards.