Both teams came out ice cold and the score stood at 5-3 almost 5 minutes in. But George Washington (6-2) went on a 14-2 run - including a 3-pointer by Nick Griffin - and later an 11-2 run to secure a 42-22 lead at the break.
DePaul (6-2) got its deficit to 14 midway through the second half after a 7-0 run but couldn't close the gap. The Blue Demons were led by Myke Henry's 22 points and six rebounds. Jamee Crockett had 16 points and Billy Garrett Jr. added 10 points and four assists.