Ja'Mill Powell scored 13 points and the Colonels (5-3) ended a three-game losing streak.
Eastern Kentucky led 13-8 on a layup by Stutz and pulled ahead 26-16 after a 3-pointer by Jonathan Hood. Brennan put IUPUI up by one, 32-31, with a dunk with 33 seconds to play, but Walden hit a 3-pointer - one of four in the half - and the Colonels led 34-32 at halftime.
Jaylen Babb-Harrison hit a 3 to spark a 17-2 run and the Colonels pulled to a 61-39 second-half lead. The Jaguars replied with a 12-2 run, but couldn't catch up.