Lawrence Alexander drilled a 3 and added a layup in the first 3 minutes to spark an 11-0 run to open the game for North Dakota State.
The Bison held North Dakota to just 19 first-half points and fashioned a 24-point lead by intermission.
North Dakota State (5-4) shot an even 50 percent from the field (25 of 50) and connected on 5 of 17 from the perimeter to control the game, adding 16 of 19 from the line. Brown scored 18 points and Werner added 17 off the bench.
North Dakota (3-6) struggled from the floor, hitting 17 of 51 attempts (33.3 percent) and just 2 of 13 from distance. Lenny Antwi led the effort with nine points.