Old Dominion started with a 20-4 run and built a 41-21 halftime lead. Ambrose Mosley's 3-pointer stretched the Monarch's lead to 67-35 with 6:33 to play.
Khary Doby scored 16 points, Bruce Beckford had 15 points and Denzel Keyes 10 to lead North Carolina A&T (1-10). Austin Williams added seven points and seven assists. The Aggies shot just 19 of 48 for 39.6 percent from the floor, and was 6 of 22 from long range.