Appalachian State scored the first 10 points and the last six points of the first half and took a 32-27 at intermission.
Charlotte hit 4 of its first 6 shots of the second - including 3-pointers by Braxton Ogbueze and Terrence Williams - to tie at 37. An 11-4 run midway through the frame gave the 49ers a five-point lead and while the Mountaineers got it to two points on two occasions, they never got over the hump.
Frank Eaves paced Appalachian State with 20 points, despite shooting 4 of 11 from the floor. He was 11 of 13 from the line.