WKU (6-5) shot 57.1 percent from the floor and 10 of 20 from 3-point range. The Hilltoppers opened on a 16-2 run, led 40-18 at halftime and never trailed.
WKU improved to 5-2 in the month December and close the month out on Monday hosting Alice Lloyd, another NAIA opponent. The 47-point margin was Western Kentucky's first 40-point victory since 2006.
Decarlos Collier led Brescia with 10 points. The Bearcats had 22 turnovers and struggled from the floor with 29.3 percent shooting.