Murray State (10-4) has now won eight consecutive games.
The Racers ran out to a 25-5 lead midway in the first half and were up 43-17 at the break. Alabama A&M never challenged.
Murray State started hot and stayed that way, making 29 of 55 from the floor (52.7 percent) while limiting the Bulldogs to just 11-of-45 shooting (24.4 percent). The Racers dominated underneath grabbing 41 rebounds compared to 26 for Alabama A&M. Murray State also had 20 assists and nine steals.
Marcus Merriweather had 11 points for A&M (1-9).