Hobbie had 12 points, hitting all three of the Bears' 3-pointers. Leland King added 11 points and Steven Spieth had 10 as Brown (8-7) moved within one victory of matching the school record for most non-league wins.
Kuakumensah, the two-time Ivy League Defensive Player of the Year, had 14 rebounds as the Bears had a 45-33 advantage, and blocked six shots, moving him up two spots to fourth in league history with 199.
Hobbie had all three of his 3s in the first half as Brown opened a 29-19 lead. Lowell only shot 25 percent in the first half.