Toledo's Julius Brown missed a game-tying 3-pointer with 7 seconds left and Central Michigan grabbed the rebound and ran out the clock.
Rayshawn Simmons scored 16 points, on 7-of-13 shooting, with six rebounds and five assists for Central Michigan (11-1). Chris Fowler added 14 points, seven rebounds and five assists. Simons hit two 3-pointers and finished with nine points.
Central Michigan ended a six game losing streak to Toledo and handed the Rockets their sixth loss in their last seven MAC openers.
Toledo made four 3-pointers in the first half to hold a 31-29 edge at the break. The Rockets finished the game 7 of 18 from beyond the arc.