Jacobi Boykins chipped in 13 points for the Bulldogs (12-4, 3-0 Conference USA), who shot above 50 percent in field goals (29 of 53) and 3-pointers (12 of 22).
The contest saw no more than a five-point difference in the opening half, and UTSA entered the break leading by one after an 8-2 run.
The Bulldogs went on a 16-5 run with 12:36 left to play for the first double-digit lead of the game. UTSA (7-7, 2-2) was unable to recover, getting no closer than seven points the rest of the way. Appleby scored 16 of his 25 points in the second half for Louisiana Tech.