North Carolina Central won its 28th straight at home as coach LeVell Moton picked up his 100th career victory in six seasons at his alma mater.
South Carolina State had an early lead but McDonald nailed a 3-pointer and followed with a layup, starting a 22-9 run that led to a 38-21 halftime advantage. The Bulldogs never threatened in the second period.
The Eagles made 27 of 58 field goal attempts (46.6 percent) while limiting South Carolina State to 15-of-53 shooting (28.3 percent).
Edward Stephens had 11 points for the Bulldogs (4-13, 2-1).