Leading by six at the break, the Tigers broke it open early in the second half by pouring in 13 unanswered points, including a dunk from Shaq Goodwin to ignite the run, to make it 48-30 with 9:11 to go. They continued to pull away down the stretch.
Memphis held Houston (7-8, 0-4) to just 33 percent shooting on 48 attempts from the floor. The Tigers hit 23 of 53 from the field and edged the Cougars at the foul line, 12-8, in made free throws.
Jherrod Stiggers made three 3-pointers and had 13 points for Houston.