Hampton (8-8, 4-0 Mid-Eastern) used a 7-2 spurt early to open a 14-6 lead, then Florida A&M went scoreless for 5:23 during which the Rattlers missed four shots and turned it over five times. Hampton led 42-28 at the half.
The lead stretched beyond 20 with 14:25 left on Reginald Johnson's layup at 58-37 and Hampton cruised to the win.
Johnson finished with 15 points and a career-high six steals. Dwight Meikle added 12 points and seven rebounds as Hampton shot 49 percent from the floor, had 17 team assists, 13 steals and six blocked shots.
The Rattlers 17-game losing streak is a school record and the longest active streak in Division I.