Both teams shot 46 percent for the game, but the Panthers (4-14, 2-3 Southwestern Athletic Conference) launched 18 more attempts while taking advantage of 23 Grambling State turnovers which led directly to 28 points.
Prairie View, which led by as many as 17, built a 15-point lead by halftime and maintained it through the final 20 minutes.
Scott finished with 16 points, knocking down 8 of 17 shots from the floor but going 0 for 6 from distance. Onwukamuche finished with 15 points and grabbed eight rebounds.
Isiah Patterson was 5 of 6 from beyond the arc and finished with 17 points to lead the Tigers (2-14, 0-6), but was the only shooter to reach double figure scoring.