Moundou-Missi's three-point play gave Harvard a 58-55 lead with 3:44 left. He hit an open baseline jumper three minutes later for a five-point lead.
Zena Edosomwan had 13 points, four in the final two minutes, and grabbed eight rebounds for Harvard (11-4). Wesley Saunders added 12 points. Harvard was just 9 of 27 (33 percent) from the field in the first half and 14 of 28 in the second.
Bryant, whose four-game winning streak was snapped, will play Pittsburgh on Feb. 2 in its final non-conference game.