Prairie View started fast, jumping out to a 26-7 lead midway of the first period and ran to a 47-23 halftime advantage. They were ahead 70-43 with 8:55 left. The Bulldogs never challenged.
Prairie View has now won four of its last five games.
The Panthers made 36 of 65 from the field while limiting Alabama A&M to 23-of-57 shooting.
Ladarious Tabb made 14 of 28 field goal attempts to finish with 30 points. He also grabbed 14 rebounds for Alabama A&M (5-13, 4-4). Tyler Davis contributed 11 points.