The score was tied at 13 midway through the first half but South Dakota State pulled away by the break, leading by nine. Parks made back-to-back layups, a free throw, and another layup to give the Jackrabbits a 14-point lead with 17:48 to play.
Daniel Amigo made a layup and two free throws with 7:06 remaining for the Pioneers, who trailed by 15 points. Denver (9-13, 3-6) didn't score again, missing its next nine shots and turning the ball over twice in the final minutes.
Amigo scored 14 points, the only Denver player to finish in double figures.