Central Michigan (15-4, 5-3 Mid-American) took an early 12-4 lead on Fowler's jumper just over five minutes in and led 41-31 at the break.
Central Michigan responded with an 11-4 run, capped by Fowler's layup with 2:11 to go that made it 69-58.
Simons finished with 16 points and nine rebounds for Central Michigan. Austin Stewart added 10 points.
Ohio (7-12, 2-6 Mid-American) placed four in double figures. Javarez Willis scored 14 points, Campbell and Ryan Taylor had 12 apiece and Maurice Ndour added 11 points and 14 boards. The Bobcats were just 5 of 18 from beyond the arc.