USC-Upstate shot 45.8 percent from the field and dominated the glass, outrebounding St. Andrews 57-28 including a 24-9 edge on the offensive glass. The Spartans entered the game leading the Atlantic Sun Conference in offensive rebounding at better than 13 per game and are 14-4 this season when shooting over 40 percent.
The Spartans started on a 17-6 run and led 51-18 at the break.
Titus Gary led St. Andrews with 10 points and KwaSean McCaskell added eight points.
The game was only the second meeting between the two schools all-time, the first coming in 1998.