Indiana State (12-12, 8-4 Missouri Valley) hit 10 of 19 from long range and shot 57.5 percent overall from the floor.
Brenton Scott matched career-highs with four 3-pointers and 21 points. Justin Gant scored 12 points, Jake Kitchell chipped in 10 and Tre' Bennett matched a career-best with six assists for the Sycamores.
Indiana State built a 34-28 lead at the break and hit 11 of 14 field goals to start the second half. The Sycamores stretched their lead to 17 points with 5:59 left to play and cruised from there.