A 15-0 run to open the second half gave the Mountaineers a 47-32 lead with 10:45 to play. CCSU (3-22, 1-11), which has lost 15 of its last 16, trailed by double digits the rest of the way.
The Blue Devils shot a season-low 28.6 percent (16 of 56) and hit just 3 of 12 from behind the arc. Their 14 second-half points, on 5-of-24 (20.8 percent) shooting, were the fewest in a half this season.
Mount Saint Mary's made 11 of 22 3-point shots.
Faronte Drakeford led CCSU with 15 points and nine rebounds.