South Carolina Upstate (18-7, 5-3 Atlantic Sun) raced out to a 13-5 lead, and then went on a 16-0 run later in the half - including four 3-pointers by three shooters - and led 38-24 at intermission.
The Spartans then opened the second half with a 21-3 run, including six points in the paint from Michael Buchanan, to more than double the score at 59-27.
Buchanan had nine rebounds to go with his eight points. Fred Miller scored 11 points with seven boards and Josh Cuthbertson added 10 points. The Spartans shot 47 percent from the floor and were 12 of 12 from the line.
Yonel Brown led Kennesaw State (8-17, 2-6) with nine points.