Memphis shot 45 percent from the field, held an 18-8 advantage in total assists, and outscored the Bulls 35-6 off the bench.
Memphis trailed just once, very early in the first half, and held a 31-21 lead at halftime. The Tigers had a 24-4 run midway through the second have to push their lead past 20.
Ruben Guerrero led South Florida (7-19, 1-12) with 17 points, six boards, and three blocks. The Bulls have lost 11 straight, and have just one win since the calendar turned to 2015.