Julien Lewis had 13 points and Paul Watson added eight for the Bulldogs (13-15, 8-7 Mountain West Conference), who remain in sixth place in the conference. Wyoming (21-7, 10-5) falls into a fourth-place tie with Utah State.
The lead changed hands eight times and no more than four points separated the teams in the second half until a Lewis layup gave Fresno State a 59-54 lead with 2:19 to play. An Alex Davis dunk made it 61-57 with 18 seconds remaining and the Bulldogs held on for the win.
Wyoming's Riley Grabau sank a pair of 3-pointers and Josh Adams hit another to start the first half, but the Cowboys saw their lead erode as Fresno State went up 18-15 on an Emmanuel Owootoah 3 and the Bulldogs led 25-21 at halftime.