Fifth-seeded McNeese State will play No. 8 seed Southeastern Louisiana on Wednesday in the opening game of Southland Conference tournament.
Central Arkansas, which didn't qualify for the league tournament, tied it up with 32 seconds left before Desharick Guidry made the game-winner with seven seconds left.
Thatch Unruh's long 3-pointer at the buzzer hit off the back rim.
Jordan Howard led Central Arkansas (2-27, 2-16) with 15 points.