It was the most points scored for Chicago State since losing to Troy State 140-131 in 1995.
Jawad Adekoya and Kieran Woods scored 16 points, and Elliot Cole added 16 points with five assists. The Cougars made a school-record 56 field goals, and matched a school-record with 26 steals, with Woods leading with four.
Anthony Mosley scored 26 points and Jake Digiorgio had 15 points to lead the Scarlet Hawks.
The Cougars opened on a 30-9 run and never trailed while building a 66-42 halftime lead. Jordan Madrid-Andrews made consecutive layups and the Cougars opened the second half on a 14-5 run. They outscored the Scarlet Hawks 71-17 in the second half.