The Tigers' Dedric Lawson finished with 13 points and Trashon Burrell had 11. Memphis surged to a 24-6 lead and was never threatened.
Memphis played efficiently on offense and only committed seven turnovers to 19 for the Golden Eagles.
Southern Miss did manage to hold a rebounding edge against the Tigers 48-37.
Eddie Davis scored 13 points for the Eagles who managed only 27 percent shooting for the game. Michael Ramey had 10 points for the Golden Eagles.