Huff hit a 3 and then Thomas hit two more to start an 18-6 run which put Creighton up by 18 with 2:47 left in the first half. Texas Southern trailed by double digits the rest of the way and the Bluejays led by as many as 34 in the second half.
Creighton made 38 of 72 (53 percent) field goals, including 10 3-pointers.
Chris Thomas led Texas Southern (0-2) with 26 points on 10-of-14 shooting. Riley Malcolm added 18 points and nine rebounds.