Nzege made 9 of 11 field goals, White hit 6 of 7 as East Carolina (2-0) shot 57 percent (30 of 53) from the field, including 7 of 11 from 3-point range. Prince Williams scored 15 on 6-of-7 shooting and Clarence Williams finished with nine points and 11 rebounds.
White hit a jumper that gave East Carolina a 25-24 lead with 6:09 left in the first half and never again trailed.
Williams' layup made it 45-35 fewer than 30 seconds into the second half, but Charlotte (0-2) scored 16 of the next 22 and tied it on a layup by Anthony Vanhook with 14:14 remaining. ECU responded with a 14-2 run and the 49ers wouldn't threaten again.
Adrien White led the 49ers with 21 points.