Green's 3-pointer in the final minute of the first half sent Hofstra (2-0) into the intermission with a 37-29 lead. The Pride opened the second half with a 35-11 stretch and led by no less than 20 from there.
Hofstra finished with 59 second-half points with the help of 64 percent shooting from the field.
Jaylen Morris led the Lions with 15 points. Kevin Bowles and Charlie Marquardt each chipped in 11, and Chucks Obunse scored 10.
Molloy never led after the opening minutes but stayed close throughout the first half.