UNLV went on a 47-4 spurt over the final 10:32 of the first half to take a 60-14 halftime lead. The Runnin' Rebels' lead reached the winning margin of 62 with 8:32 left in the second half.
UNLV made 54 percent of its shots, including 13 of 27 3-pointers.
Jonathon Mines led New Mexico Highlands with 12 points and Kendrick Nichols added 10. The Cowboys shot just 28 percent and turned it over 27 times. UNLV scored 43 points off the turnovers.