Jeremy Senglin had 16 points to lead the Wildcats and made 3 of 4 from 3-point range.
Richaud Gittens added 14 points for Weber State (1-2), which shot 13 of 23 from long range and 56.9 percent overall.
Antelope Valley started the game with a 9-3 lead. Weber State answered with a 35-7 run and led by no less than 17 from there.
The Wildcats had their largest lead at 90-45 just before Josh Sanchez's dunk for the Pioneers capped the scoring.
Sanzhez had 18 points on 8-of-14 shooting and Joe McNiff added 9, going 3 of 4 from 3-point range. The rest of the Pioneers shot 7 of 38.