Brett Bisping and Lavon Long added 13 points apiece for the Saints (1-2), who had opened the season with losses to then-No. 5 Duke and No. 17 Wisconsin. Siena is the first school to open against the defending national champion and runner-up since the NCAA Tournament field expanded to 64 teams in 1985.
Siena made 22 of 25 free throws and outrebounded the Highlanders 45-31.
The Saints closed the half with an 8-1 run for a 31-24 lead and then opened the second half with an 11-0 spurt, seven from Bisping, to lead 40-24. Long scored six straight in a late 8-0 surge to clinch it.