The Anteaters (4-0) are off to their best start since opening the 1982-83 season 5-0.
UC Irvine was 24 of 56 (42.9%) from the floor while limiting the Broncos to 17-of-67 (25.4%) shooting.
The Anteaters sprinted to a 29-6 lead with 6:38 remaining in the first half and held a 35-19 halftime advantage. They kept pressing and led 60-34 with 10:06 left in the game.
Jared Brownridge, who made 11 of 12 free throws, led Santa Clara (0-5) with 19 points.