Johnny Griffin paced Loyola with 21 points on 10-of-14 shooting.
An 11-0 run early in the game - including 3s by Jay Hedgeman and Long -opened things up for the Cajuns. Another nine-point run later in the frame enabled Louisiana-Lafayette to lead 50-33 at intermission.
The lead hit 30 points midway through the second half after Long made a free throw, layup and dunk.
NAIA member Loyola made one basket in the final four minutes of the game.