Yale dominated the boards, outrebounding Bryant 51-30. Four Yale players had at least seven boards. Bryant has not outrebounded an opponent this season.
Bryant (2-6) lost its fifth straight game and remained winless on the road. Dan Garvin led the Bulldogs with nine points, the closest to double figures.
After Bryant came within 24-20 in the first half, Yale closed on a 12-4 run to lead 36-24 at the break and kept the lead in double digits the rest of the way.
Yale had 17 assists - Mason had six - on 26 field goals. Bryant shot 28 percent (15 of 53) from the field.