Towson has won five straight, including four at home, after a 1-3 start to the season.
The Tigers never trailed in the game, opening on a 20-7 stretch capped by a Jordan McNeil layup off an assist by Eddie Keith II. Keith tied for a game-high five assists with Sacred Heart's Cane Broome. Towson led 42-25 at halftime.
The Tigers lead never dipped below 10 points in the second half and reached as high as 25 after a McNeil jumper with 6:56 left.