Oral Roberts led by 25 points at halftime and used a 13-0 run, including a dunk and 3-pointer by Emegano, early in the second half to further secure it.
Jeffries and Albert Owens grabbed nine rebounds apiece as Oral Roberts outrebounded John Brown 60-38.
Griffin Brady led John Brown with 13 points and Ricky Roberts added 11. The pair combined for 9-of-27 shooting as John Brown was held to 27 percent. Ten of John Brown's 20 field goals were from 3-point range.