Denver held the Toreros (3-6) to just 31.6 percent from the field and a paltry 4 of 25 from behind the arc.
The Pioneers had a 9-0 run in the first half and led 25-19 at the break. Daniel Amigo hit a jumper off an assist by Engesser to give Denver its largest lead of the game, 41-29, with 10:55 remaining.
Vasa Pusica made a jumper to pull San Diego to 52-44 with 3:19 left, but the Toreros did not get closer.
Pusica and Brett Bailey scored 11 points apiece for San Diego.