The last time the Ospreys won by more than 40 points was in their 106-60 victory over Trinity Baptist on Jan. 6.
Trent Mackey scored 17 points with five 3-pointers, Nick Malonga scored 15, and Aaron Bodager added 14 with four 3-pointers. Dallas More scored 13, Chris Davenport 10 and the Ospreys (7-4) shot 62 percent from the field.
Up 62-33 at halftime, North Florida led 82-43 with 13:56 left after Bodager and Mackey each hit 3s. Moore's free throw put North Florida up 100-58 and the Ospreys cruised.