Holy Cross (4-6) snapped a three-game skid, and bounced back after a 92-59 loss at No. 2 Kansas on Dec. 9. The Crusaders shot a season-high 66 percent from the floor and had their largest win of the season.
Pancake Thomas had 16 points to lead Hartford (3-8), which has lost six straight.
The Crusaders used a 22-8 run to take a 36-16 lead with 6:49 left in the first half, and built a 45-26 halftime lead.
Holy Cross had a 13-5 spurt and forced three turnovers to open the second half and stretched its lead to 56-31 with 16:31 to play.