Williams now has eight games of 20 points or better. Toledo outrebounded the Aggies 47-34 and had 22 assists on 31 field goals while only committing nine turnovers.
Boothe made or assisted on four of the Rockets' first five baskets - making two shots and feeding Williams for a pair of 3-pointers as the Rockets built a 12-2 lead. Sanford also scored in the opening flurry.
Toledo scored 22 points at the free-throw line as N.C. A&T was called for 26 fouls.