Karena scored seven of the Racers' first nine points to jump-start his team. Karena's layup, free throw and dunk in succession gave Murray State a 9-7 lead. Karena scored 14 first-half points.
With a 36-23 lead at the break, Karena and Yoho hit jumpers to make it 40-31.
Damarcus Croaker hit a layup, Jeffrey Moss made a 3 and Wayne Langston's 3 cut the lead to 40-39 with 14:43 left. But the Raiders used a 15-3 run over the next four minutes and Murray State never threatened again.
Moss lead Murray State (5-7) with 12 points and Croaker chipped in nine.