Lee Vanderhorst led the NAIA Knights with 15 points off the bench. The Knights shot just 25 percent and committed 25 turnovers.
The outcome was decided early. Charleston Southern was leading by seven when Wallace hit three 3-pointers during a 15-0 run in the first half. Wallace made another 3-pointer in an 8-0 run, and the Buccaneers led by 29 points at halftime.
A pair of 12-0 runs in the second half led to a 59-point advantage with 4:10 remaining.
The game was an exhibition for St. Andrews.