After a low-scoring first half, Radford had come within 38-34 when Rashun Davis made three free throws after being fouled on a 3-point attempt. But the Highlanders scored just two more points over the next seven minutes while High Point extended the lead to 20, 56-36, with 11:12 to play.
Anthony Lindauer added 13 points for the Panthers (10-4, 3-0 Big South).
High Point shot 50 percent from the field (31-62) with 19 assists on the 31 field goals and just six turnovers. The Panthers also notched nine steals as Radford committed 16 turnovers. High Point shot 63 percent in the second half.