The Pride (10-4, 2-0 Colonial Athletic Conference) outscored Towson 45-29 in both halves to win their fourth straight.
Mike Morsell's jumper pulled Towson (10-5, 1-1) within 24-21 with 7:23 left in the first half. Hofstra closed the period on a 21-8 run and maintained a double-digit lead throughout the second half.
William Adala Moto had 14 points to lead Towson, which had its three-game winning streak snapped. Morsell added 12 and Walter Foster had 10 points and 10 boards.