The Cardinals, who have averaged 42 rebounds a game, grabbed 46 compared to Nicholls' 34. Lamar made 28 of 67 shots from the field while limiting the Colonels to 15-of-47 shooting.
Lamar held a 30-24 halftime advantage and extended that to 62-46 with 6:44 remaining.
Tre O'Neal nailed a 3-pointer to start a 9-0 run as the Colonels pulled to 75-65 with 1:14 left. Garth and Booze made four free throws to seal the win.
Ja'Dante' Frye led the Colonels (4-10, 0-1) with 17 points.