Wichita State (8-5, 2-0 Missouri Valley) had seven players score between six and 14 points and the Shockers shot over 55 percent (27 of 49) as a team.
Bradley (2-13, 0-2) was led by Dwayne Lautier-Ogunleye with nine points. The Braves committed 23 turnovers and made 6 of 22 beyond the arc.
The Shockers made a 12-0 run over 5:04 in the first half to build a 48-24 lead at intermission.
Bradley didn't score for nearly four minutes to start the second half, turning it over four times in the span, and Wichita State's lead hit the 30-point mark with 9:47 left on a layup by Eric Hamilton.